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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HR All Species: 16.06
Human Site: S538 Identified Species: 44.17
UniProt: O43593 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43593 NP_005135.2 1189 127495 S538 D T A T N S S S E E G P G S G
Chimpanzee Pan troglodytes XP_519644 1189 127418 S538 D T A A N S S S E E G P G S G
Rhesus Macaque Macaca mulatta NP_001028015 1187 127116 S536 D T A A N S S S E E G P G S G
Dog Lupus familis XP_543256 1209 129846 S560 E E D S A A S S E E G G G S G
Cat Felis silvestris
Mouse Mus musculus Q61645 1182 127174 E533 E D S S A T S E E G G G G P G
Rat Rattus norvegicus P97609 1181 127289 S532 E E D S C A T S E E G G G S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511537 1285 142386 S566 K Y D L E A I S L W L P V A K
Chicken Gallus gallus Q5ZIX8 1325 149315 P604 L T P N K Y D P E A I S L W L
Frog Xenopus laevis Q5HZN1 1334 149927 N623 K Y D A E A I N L W L P L A S
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 95.2 82.3 N.A. 79.6 78.9 N.A. 22.1 22.2 21.7 N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 98.9 97.1 86.7 N.A. 85.4 84.9 N.A. 37 37.5 35.8 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 93.3 53.3 N.A. 33.3 40 N.A. 13.3 13.3 6.6 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 93.3 93.3 73.3 N.A. 60 66.6 N.A. 26.6 13.3 26.6 N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 34 34 23 45 0 0 0 12 0 0 0 23 0 % A
% Cys: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 34 12 45 0 0 0 12 0 0 0 0 0 0 0 0 % D
% Glu: 34 23 0 0 23 0 0 12 78 56 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 12 67 34 67 0 56 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 23 0 0 0 12 0 0 0 0 % I
% Lys: 23 0 0 0 12 0 0 0 0 0 0 0 0 0 12 % K
% Leu: 12 0 0 12 0 0 0 0 23 0 23 0 23 0 12 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 12 34 0 0 12 0 0 0 0 0 0 0 % N
% Pro: 0 0 12 0 0 0 0 12 0 0 0 56 0 12 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 12 34 0 34 56 67 0 0 0 12 0 56 23 % S
% Thr: 0 45 0 12 0 12 12 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 23 0 0 0 12 0 % W
% Tyr: 0 23 0 0 0 12 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _